Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | PDE8B | O95263 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.31 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27627479 | 0.84 | CYP19A1 (0.38) | CYP19A1CYP11B1KEAP1SLC9A1NOTUM | |
| SCHEMBL6224234 | 0.80 | CYP19A1 (0.38) | CYP19A1CYP11B1KEAP1SLC9A1NOTUM | |
| SCHEMBL27565161 | 0.80 | TGFBR1 (0.41) | BRD4TGFBR1 | |
| SCHEMBL27608277 | 0.74 | SLC9A1 (0.41) | KEAP1SLC9A1NOTUMNSD2TGFBR1 | |
| SCHEMBL4065212 | 0.73 | HCAR3 (0.42) | KEAP1SLC9A1NOTUMNSD2BRD4 | |
| SCHEMBL27584907 | 0.73 | GRM5 (0.39) | TGFBR1 | |
| SCHEMBL15341829 | 0.68 | CYP19A1 (0.50) | CYP19A1CYP11B1KEAP1SLC9A1NOTUM | |
| SCHEMBL9523659 | 0.66 | CYP19A1 (0.50) | CYP19A1CYP11B1KEAP1SLC9A1NSD2 | |
| SCHEMBL4029836 | 0.64 | TGFBR1 (0.38) | KEAP1SLC9A1TGFBR1 | |
| SCHEMBL4032039 | 0.64 | FAAH (0.38) | KEAP1SLC9A1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1681805-A | Novel imidazole compounds as transforming growth factor (TGF) inhibitors | PFIZER PROD INC (US) | 2005-10-12 | — | — | CN | disclosed |