Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | CTSA | P10619 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31079392 | 0.87 | SLC6A3 (0.52) | ACMSDKDM4EALDH1A1HPGDERN1 | |
| SCHEMBL31079420 | 0.87 | ACMSD (0.51) | ACMSDIDO1ALDH1A1ERN1CTSA | |
| SCHEMBL410761 | 0.84 | TTR (0.65) | ACMSDKDM4EIDO1ALDH1A1HPGD | |
| SCHEMBL6536000 | 0.84 | MCL1 (0.54) | ACMSDKDM4EIDO1ALDH1A1HPGD | |
| SCHEMBL4049992 | 0.83 | ACMSD (0.61) | ACMSDKDM4EALDH1A1HPGDPTPN11 | |
| SCHEMBL27838174 | 0.82 | DHODH (0.53) | KDM4EIDO1ALDH1A1HPGDPTPN11 | |
| SCHEMBL4602451 | 0.82 | PTGS2 (0.56) | ACMSDKDM4EALDH1A1HPGDPTPN11 | |
| SCHEMBL4600237 | 0.81 | LMNA (0.60) | KDM4EIDO1ALDH1A1HPGDNR1I2 | |
| SCHEMBL18742254 | 0.81 | ACMSD (0.76) | ACMSDKDM4EALDH1A1HPGDDHODH | |
| SCHEMBL14252244 | 0.81 | ACMSD (0.76) | ACMSDKDM4EALDH1A1HPGDDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4448504-A1 | NAPHTHALENE AND QUINOLINE ANALOGS AS RXFP1 AGONISTS | Bristol-Myers Squibb Company (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023114818-A1 | NAPHTHALENE AND QUINOLINE ANALOGS AS RXFP1 AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-22 | — | — | WO | disclosed |
| CN-101413143-B | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INST | 2013-09-18 | — | — | CN | disclosed |
| CN-101413143-A | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INST (US) | 2009-04-22 | — | — | CN | disclosed |
| CN-100448852-C | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INST (US) | 2009-01-07 | — | — | CN | disclosed |
| CN-1747965-A | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INST (US) | 2006-03-15 | — | — | CN | disclosed |