Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CTSV | O60911 | 3/20 | 0.47 |
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 6/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1845491 | 0.86 | HTR6 (0.59) | POLBCTSVCTSLMAPTCYP1A2 | |
| SCHEMBL3049503 | 0.86 | MAPT (0.59) | POLBMAPTCYP3A4NPSR1MEN1 | |
| SCHEMBL7940000 | 0.81 | ALDH1A1 (0.57) | POLBCTSVCTSLMAPTNPSR1 | |
| SCHEMBL12497140 | 0.81 | MAPT (0.48) | POLBMAPTCYP1A2CYP2C19HTR6 | |
| SCHEMBL2763441 | 0.79 | HTR6 (0.48) | MAPTCYP3A4HTR6MEN1KMT2A | |
| SCHEMBL2763067 | 0.79 | ALDH1A1 (0.60) | MAPTCYP1A2CYP2C19SIRT6MEN1 | |
| SCHEMBL4802434 | 0.79 | KMT2A (0.56) | POLBCTSVCTSLMAPTNPSR1 | |
| SCHEMBL4802423 | 0.79 | KMT2A (0.56) | POLBCTSVCTSLMAPTNPSR1 | |
| SCHEMBL12497148 | 0.76 | ALDH1A1 (0.44) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12497382 | 0.76 | SIRT6 (0.44) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320897-B1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | TREVENTIS CORP (US) | 2014-01-15 | — | — | EP | disclosed |
| WO-2010025375-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | TREVENTIS CORPORATION (US) | 2010-03-04 | — | — | WO | disclosed |