Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807710 | 0.84 | ALDH1A1 (0.42) | TPMTHTR7NOTUMHTTSMN1; SMN2 | |
| SCHEMBL8297284 | 0.71 | HTR7 (0.70) | HTR7ALDH1A1LMNAMEN1NPC1 | |
| SCHEMBL5226007 | 0.69 | POLB (0.39) | HTR7MAPT | |
| SCHEMBL7434160 | 0.67 | ALDH1A1 (0.50) | TPMTHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL5741843 | 0.66 | GPR84 (0.43) | HTTALDH1A1MTNR1AMTNR1BLMNA | |
| SCHEMBL1613916 | 0.65 | TPMT (0.68) | TPMTSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL1144695 | 0.65 | NOTUM (0.47) | TPMTNOTUMALDH1A1 | |
| SCHEMBL31721465 | 0.64 | ALDH1A1 (0.50) | TPMTHTTSMN1; SMN2ALDH1A1DAO | |
| SCHEMBL25610863 | 0.63 | TPMT (0.65) | TPMTNOTUMSMN1; SMN2ALDH1A1DAO | |
| SCHEMBL21315697 | 0.63 | TNF (0.58) | HTR7ALDH1A1LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1809573-A | Tricyclic indole derivatives and their use in the treatment of alzheimer's disease | GLAXO GROUP LTD (GB) | 2006-07-26 | — | — | CN | disclosed |
| CN-1735592-A | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LTD (GB) | 2006-02-15 | — | — | CN | disclosed |