Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.61 |
| ▸ | MAP4K3 | Q8IVH8 | 3/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 4/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27630123 | 0.90 | MET (0.51) | METMAP4K3MAP4K4 | |
| SCHEMBL27650234 | 0.90 | MET (0.51) | METMAP4K3MAP4K4 | |
| SCHEMBL27629940 | 0.87 | MET (0.48) | METMAP4K3MAP4K4NEK2 | |
| SCHEMBL27629874 | 0.87 | MET (0.50) | METMAP4K3MAP4K4 | |
| SCHEMBL30453136 | 0.87 | MAP4K3 (0.55) | METMAP4K3MAP4K4NEK2PTPN1 | |
| SCHEMBL27630145 | 0.85 | MET (0.47) | METMAP4K3MAP4K4 | |
| SCHEMBL27630206 | 0.85 | MET (0.59) | METMAP4K3MAP4K4 | |
| SCHEMBL30454707 | 0.82 | MAP4K3 (0.58) | METMAP4K3MAP4K4 | |
| SCHEMBL487859 | 0.82 | MAP4K3 (0.58) | METMAP4K3MAP4K4 | |
| SCHEMBL27650130 | 0.81 | MET (0.52) | METMAP4K3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1777427-A | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN INC (US) | 2006-05-24 | — | — | CN | claimed |
| CN-1777427-A | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN INC (US) | 2006-05-24 | — | — | CN | disclosed |