Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2763234 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1SIGMAR1TMEM97 | |
| SCHEMBL2623654 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1SIGMAR1TMEM97 | |
| SCHEMBL16799707 | 0.89 | LMNA (0.42) | SMN1; SMN2KMT2AMEN1SIGMAR1TMEM97 | |
| SCHEMBL16799709 | 0.89 | LMNA (0.42) | SMN1; SMN2KMT2AMEN1SIGMAR1TMEM97 | |
| SCHEMBL20810547 | 0.88 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1SIGMAR1TMEM97 | |
| SCHEMBL16800065 | 0.87 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1SIGMAR1TMEM97 | |
| SCHEMBL16800066 | 0.87 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1SIGMAR1TMEM97 | |
| SCHEMBL16800064 | 0.87 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1SIGMAR1TMEM97 | |
| SCHEMBL20810390 | 0.86 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2AMEN1SIGMAR1TMEM97 | |
| SCHEMBL16799902 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AMEN1SIGMAR1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160107984-A1 | MODULATOR | UNIVERSITY COLLEGE LONDON (GB) | 2016-04-21 | — | — | US | disclosed |
| US-9120723-B2 | Modulator | CANBEX THERAPEUTICS LIMITED (GB) | 2015-09-01 | — | — | US | disclosed |
| US-20130123356-A1 | MODULATOR | UNIVERSITY COLLEGE LONDON (GB) | 2013-05-16 | — | — | US | disclosed |
| EP-2177503-B1 | MODULATORS OF CANNABINOID RECEPTORS | UCL BUSINESS PLC (GB) | 2013-04-10 | — | — | EP | disclosed |
| US-8293796-B2 | Modulator | UNIVERSITY COLLEGE LONDON (GB) | 2012-10-23 | — | — | US | disclosed |
| US-20100144876-A1 | MODULATOR | UNIVERSITY COLLEGE LONDON (GB) | 2010-06-10 | — | — | US | disclosed |
| EP-2177503-A1 | MODULATORS OF CANNABINOID RECEPTORS | UCL Business PLC (GB) | 2010-04-21 | — | — | EP | disclosed |
| US-7696382-B2 | Modulator | UNIVERSITY COLLEGE LONDON (GB) | 2010-04-13 | — | — | US | disclosed |
| EP-1745011-B1 | MODULATORS OF CANNABINOID RECEPTORS | UCL BUSINESS PLC (GB) | 2009-09-30 | — | — | EP | disclosed |
| US-20080114062-A1 | Modulator | UNIVERSITY COLLEGE LONDON WOLFSON INSTITUTE FOR BIOMEDICAL RESEARCH (GB) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114062-A1 | Modulator | CHRNA3, CHRM3, NR3C2 | SMN1; SMN2 261/4885KMT2A 2468/4885MEN1 3055/4885 |
| US-20160107984-A1 | MODULATOR | CHRNA3, CHRNB3, CHRM3 | SMN1; SMN2 106/4885KMT2A 2594/4885MEN1 2544/4885 |
| US-20130123356-A1 | MODULATOR | MRGPRX2, NR3C2, MC2R | SMN1; SMN2 3589/4885KMT2A 3127/4885MEN1 1627/4885 |
| US-20100144876-A1 | MODULATOR | CHRNA3, CHRM3, NR3C2 | SMN1; SMN2 261/4885KMT2A 2468/4885MEN1 3055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.