Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628648 | 0.76 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL31298641 | 0.74 | GPR3 (0.34) | KDM4EALDH1A1HSD17B10POLBMAPT | |
| SCHEMBL10371646 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL13030846 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL823488 | 0.74 | GSK3B (0.45) | KDM4EALDH1A1HSD17B10HPGDLIMK1 | |
| SCHEMBL10831975 | 0.71 | MAPT (0.47) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL10103719 | 0.69 | MPO (0.42) | ALDH1A1HSD17B10HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL4420492 | 0.69 | PRKD3 (0.43) | KDM4EALDH1A1HSD17B10HPGDLIMK1 | |
| SCHEMBL14216404 | 0.69 | SLC9A1 (0.43) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL28823953 | 0.69 | ALDH1A1 (0.38) | KDM4EALDH1A1HSD17B10HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103080093-A | Indazole compounds and their uses | DANA FARBER CANCER INST INC | 2013-05-01 | — | — | CN | disclosed |
| CN-102417487-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB | 2012-04-18 | — | — | CN | disclosed |
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | disclosed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | disclosed |