Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767252 | 0.96 | KDM4E (0.49) | TP53GAAALDH1A1KDM4EMEN1 | |
| SCHEMBL2763829 | 0.81 | NOTUM (0.53) | TP53ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2765509 | 0.81 | CYP3A4 (0.45) | TP53ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2766572 | 0.76 | HTR7 (0.61) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2766091 | 0.75 | DRD2 (0.52) | TP53GAAALDH1A1KDM4EMEN1 | |
| SCHEMBL13362367 | 0.73 | PTGS2 (0.56) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL2766179 | 0.73 | ALDH1A1 (0.44) | TP53GAAALDH1A1KDM4EMEN1 | |
| SCHEMBL5679898 | 0.73 | ALDH1A1 (0.43) | TP53GAAALDH1A1KDM4EMEN1 | |
| SCHEMBL2765235 | 0.73 | TGFBR1 (0.45) | TP53GAAALDH1A1KDM4EMEN1 | |
| SCHEMBL5683622 | 0.73 | TGFBR1 (0.45) | TP53GAAALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400515-B1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | KOWA CO (JP) | 2010-04-14 | — | — | EP | disclosed |
| EP-1400515-A1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6472386-B1 | Cyclic diamine compound with 5-membered ring groups | KOWA CO., LTD. (JP) | 2002-10-29 | — | — | US | disclosed |