Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2765382 | 0.96 | TP53 (0.49) | KDM4ETP53GAAAURKADAPK3 | |
| SCHEMBL2765186 | 0.78 | HTR7 (0.57) | KDM4EALDH1A1TDP1KCNH2 | |
| SCHEMBL2763829 | 0.77 | NOTUM (0.53) | KDM4ETP53AURKADAPK3PRKACA | |
| SCHEMBL2765509 | 0.77 | CYP3A4 (0.45) | KDM4ETP53ALDH1A1MEN1KMT2A | |
| SCHEMBL2764403 | 0.77 | DRD2 (0.49) | KDM4ETP53GAAALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL2765800 | 0.75 | KDM4E (0.48) | KDM4ETP53GAAALDH1A1MEN1 | |
| SCHEMBL5683281 | 0.75 | KDM4E (0.48) | KDM4ETP53GAAALDH1A1MEN1 | |
| SCHEMBL2766065 | 0.75 | KDM4E (0.48) | KDM4ETP53GAAALDH1A1MEN1 | |
| SCHEMBL2763970 | 0.74 | KDM4E (0.49) | KDM4ETP53GAAALDH1A1MEN1 | |
| SCHEMBL5682153 | 0.73 | TP53 (0.49) | KDM4ETP53GAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400515-B1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | KOWA CO (JP) | 2010-04-14 | — | — | EP | disclosed |
| EP-1400515-A1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6472386-B1 | Cyclic diamine compound with 5-membered ring groups | KOWA CO., LTD. (JP) | 2002-10-29 | — | — | US | disclosed |