Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27717107 | 1.00 | CTSK (0.31) | CTSKTP53TSHR | |
| SCHEMBL27717130 | 1.00 | CTSK (0.31) | CTSKTP53TSHR | |
| SCHEMBL29742734 | 0.83 | — | — | |
| SCHEMBL19853433 | 0.79 | MMP8 (0.35) | TSHR | |
| SCHEMBL28012865 | 0.76 | LMNA (0.31) | TSHR | |
| SCHEMBL27632708 | 0.76 | LMNA (0.31) | TSHR | |
| SCHEMBL28012864 | 0.76 | LMNA (0.31) | TSHR | |
| SCHEMBL20095382 | 0.75 | TP53 (0.33) | TP53TSHR | |
| SCHEMBL6484596 | 0.74 | TSHR (0.38) | TP53TSHR | |
| SCHEMBL27717111 | 0.74 | LMNA (0.34) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024258-B | Pyrrolopyrazine kinase inhibitors | 霍夫曼-拉罗奇有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-101784545-B | Pyrimidine derivatives as RAF kinase inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2016-04-20 | — | — | CN | disclosed |
| CN-104370828-A | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS INC | 2015-02-25 | — | — | CN | disclosed |
| CN-104024258-A | Pyrrolopyrazine kinase inhibitors | HOFFMANN LA ROCHE | 2014-09-03 | — | — | CN | disclosed |
| CN-102659774-A | Piperidine and piperazine derivatives as P2X3 antagonists | HOFFMANN LA ROCHE | 2012-09-12 | — | — | CN | disclosed |
| CN-101784545-A | Pyrimidine derivatives as RAF kinase inhibitors | BIOGEN IDEC INC | 2010-07-21 | — | — | CN | disclosed |
| CN-101743242-A | Heterocyclic compounds useful as RAF kinase inhibitors | BIOGEN IDEC INC | 2010-06-16 | — | — | CN | disclosed |
| CN-101466712-A | Thioxanthine derivatives and their use as inhibitors of mpo | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |
| CN-101282972-A | Piperidine and piperazine derivatives as P2X3 antagonists | HOFFMANN LA ROCHE (CH) | 2008-10-08 | — | — | CN | disclosed |
| CN-1751037-A | Sulfonamide derivatives as PPAR modulators | LILLY CO ELI (US) | 2006-03-22 | — | — | CN | disclosed |