Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27642448 | 0.85 | POLB (0.47) | POLBGLSMAPTLMNAMEN1 | |
| SCHEMBL2868491 | 0.82 | KMT2A (0.57) | POLBGLSMAPTLMNAMEN1 | |
| SCHEMBL27642538 | 0.80 | ALDH1A1 (0.45) | POLBMAPTLMNAMEN1KMT2A | |
| SCHEMBL4311842 | 0.76 | POLB (0.50) | POLBGLSMAPTLMNAMEN1 | |
| SCHEMBL14910007 | 0.75 | GLS (0.65) | POLBGLSMAPTLMNAMEN1 | |
| SCHEMBL27642455 | 0.72 | LMNA (0.53) | POLBMAPTLMNAMEN1KMT2A | |
| SCHEMBL5435879 | 0.72 | GLS (0.61) | POLBGLSKMT2AHTT | |
| SCHEMBL16931094 | 0.71 | GLS (0.62) | POLBGLSMAPTLMNAMEN1 | |
| SCHEMBL17060346 | 0.70 | GLS (0.65) | POLBGLSMAPTLMNAMEN1 | |
| SCHEMBL4572853 | 0.70 | NR3C1 (0.56) | POLBGLSLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1867336-B | 1-aryl-4-substituted piperazines derivatives and pharmaceutical use thereof | CHEMOCENTRYX INC | 2010-05-12 | — | — | CN | disclosed |
| CN-100542534-C | Substituted piperazines | CHEMOCENTRYX INC (US) | 2009-09-23 | — | — | CN | disclosed |
| CN-1867336-A | 1-aryl-4-substituted piperazines derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders | CHEMOCENTRYX INC (US) | 2006-11-22 | — | — | CN | disclosed |