Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10685331 | 0.83 | ALDH1A1 (0.57) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL205522 | 0.77 | CHRNB2 (0.51) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL11070772 | 0.75 | PAX8 (0.50) | ALDH1A1HPGDMAPTTDP1MAPK1 | |
| SCHEMBL206963 | 0.75 | LTB4R (0.50) | ALDH1A1HPGDMAPTLMNA | |
| SCHEMBL8788284 | 0.75 | KMT2A (0.76) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL11867121 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL11178153 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL28131567 | 0.73 | ALDH1A1 (0.58) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL11400705 | 0.73 | ALDH1A1 (0.45) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL2615683 | 0.72 | ALDH1A1 (0.47) | ALDH1A1HPGDMAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100349895-C | Pyrrolopyridazine derivatives | ASTELLAS PHARMA INC (JP) | 2007-11-21 | — | — | CN | disclosed |
| CN-1759117-A | Pyrrolopyridazine derivatives | ASTELLAS PHARMA INC (JP) | 2006-04-12 | — | — | CN | disclosed |