Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27987390 | 0.86 | GRM2 (0.37) | — | |
| SCHEMBL27621459 | 0.86 | GRM2 (0.37) | — | |
| SCHEMBL27541465 | 0.85 | PARP15 (0.46) | TAAR1PARP15PARP10PARP14RIPK1 | |
| SCHEMBL27729878 | 0.84 | LOXL2 (0.44) | — | |
| SCHEMBL27811501 | 0.84 | REN (0.40) | — | |
| SCHEMBL3068348 | 0.84 | GRM2 (0.47) | MAOBPARP1 | |
| SCHEMBL27831468 | 0.83 | GRM2 (0.37) | — | |
| SCHEMBL27627069 | 0.83 | TAAR1 (0.46) | TAAR1PARP10RIPK1IDO1AGXT | |
| SCHEMBL27627078 | 0.83 | HTR3E (0.48) | TAAR1RIPK1IDO1AGXT | |
| SCHEMBL27532961 | 0.82 | TAAR1 (0.40) | TAAR1FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100513398-C | 2- (2-hydroxybiphenyl-3-yl) -1H-benzimidazole-5-carboxamidine derivatives as factor VIIA inhibitors | AXYS PHARM INC (US) | 2009-07-15 | — | — | CN | disclosed |
| CN-1745070-A | 2- (2-hydroxybiphenyl-3-yl) -1H-benzimidazole-5-carboxamidine derivatives as factor VIIA inhibitors | AXYS PHARM INC (US) | 2006-03-08 | — | — | CN | disclosed |