Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.51 |
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | HTR2A | P28223 | 6/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27645138 | 0.90 | HTR1A (0.60) | HTR1ADRD2HTR2ASIGMAR1CCR3 | |
| SCHEMBL27666117 | 0.87 | HTR1A (0.58) | HTR1ADRD2HTR2ASIGMAR1POLB | |
| SCHEMBL5011649 | 0.78 | SIGMAR1 (0.49) | HTR1ADRD2HTR2ASIGMAR1CCR3 | |
| SCHEMBL5015053 | 0.76 | SIGMAR1 (0.49) | HTR1ADRD2HTR2ASIGMAR1CCR3 | |
| SCHEMBL27666166 | 0.73 | HTR1A (0.43) | HTR1ADRD2HTR2ASIGMAR1CCR3 | |
| SCHEMBL27645227 | 0.72 | SIGMAR1 (0.49) | HTR1ADRD2HTR2ASIGMAR1CCR3 | |
| SCHEMBL8092982 | 0.71 | SIGMAR1 (0.85) | SIGMAR1CCR3 | |
| SCHEMBL30671733 | 0.69 | SIGMAR1 (0.97) | HTR1ADRD2HTR2ASIGMAR1CCR3 | |
| SCHEMBL5015098 | 0.68 | SIGMAR1 (0.50) | HTR1ASIGMAR1CCR3 | |
| SCHEMBL30671734 | 0.67 | SIGMAR1 (1.00) | HTR1ADRD2HTR2ASIGMAR1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |