Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 6/20 | 0.44 |
| ▸ | THRB | P10828 | 6/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282164 | 0.77 | THRA (0.59) | THRATHRB | |
| SCHEMBL27666404 | 0.75 | THRA (0.59) | THRATHRB | |
| SCHEMBL27666422 | 0.75 | THRA (0.44) | THRATHRBMAPTHSP90AA1OXTR | |
| SCHEMBL28303173 | 0.72 | KEAP1 (0.52) | THRATHRBMAPT | |
| SCHEMBL6201748 | 0.71 | NPC1 (0.49) | THRATHRBMAPT | |
| SCHEMBL3156760 | 0.71 | THRA (0.59) | THRATHRB | |
| SCHEMBL3161424 | 0.71 | THRA (0.52) | THRATHRB | |
| SCHEMBL13382158 | 0.70 | THRA (0.50) | THRATHRB | |
| SCHEMBL13382173 | 0.70 | THRA (0.52) | THRATHRB | |
| SCHEMBL3160749 | 0.69 | THRB (0.57) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101189248-A | Novel phosphorus-containing thyromimetics | METABASIS THERAPEUTICS INC (US) | 2008-05-28 | — | — | CN | disclosed |
| CN-101180097-A | Novel phosphinic acid-containing thyromimetics | METABASIS THERAPEUTICS INC (US) | 2008-05-14 | — | — | CN | disclosed |
| CN-1882327-A | Novel phosphorus-containing thyromimetics | METABASIS THERAPEUTICS INC (US) | 2006-12-20 | — | — | CN | disclosed |