Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377507 | 0.85 | CYP3A4 (0.52) | CYP3A4LMNAKDM4EFLT3ACHE | |
| SCHEMBL473532 | 0.84 | LMNA (0.52) | CYP3A4LMNAKDM4EFLT3ACHE | |
| SCHEMBL50809 | 0.82 | CYP3A4 (0.62) | CYP3A4LMNAKDM4EFLT3ACHE | |
| SCHEMBL28890049 | 0.81 | MEN1 (0.53) | CYP3A4KDM4ECA2PKMTDP1 | |
| SCHEMBL29001439 | 0.81 | KDM4E (0.61) | CYP3A4LMNAKDM4EFLT3ACHE | |
| SCHEMBL1846855 | 0.81 | MCL1 (0.57) | CYP3A4LMNAKDM4EACHEGLA | |
| SCHEMBL3331532 | 0.79 | CHRNA3 (0.49) | CYP3A4LMNAKDM4EFLT3ACHE | |
| SCHEMBL27593853 | 0.79 | LMNA (0.47) | CYP3A4LMNAKDM4EFLT3ACHE | |
| SCHEMBL12316409 | 0.79 | LMNA (0.47) | CYP3A4LMNAKDM4EFLT3ACHE | |
| SCHEMBL21921357 | 0.78 | CYP3A4 (0.58) | CYP3A4LMNAKDM4EACHEGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101326161-B | Novel compounds | ASTRAZENECA AB | 2013-04-17 | — | — | CN | disclosed |
| CN-100469769-C | Benzyl-pyridazinons as reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (CH) | 2009-03-18 | — | — | CN | disclosed |
| CN-101374804-A | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease | ASTRAZENECA AB (SE) | 2009-02-25 | — | — | CN | disclosed |
| CN-101326161-A | Novel compounds | ASTRAZENECA AB (SE) | 2008-12-17 | — | — | CN | disclosed |
| CN-100406007-C | Asthma and allergic inflammation modulators | AMGEN INC (US) | 2008-07-30 | — | — | CN | disclosed |
| CN-1764649-A | Benzyl-pyridazinones as reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (CH) | 2006-04-26 | — | — | CN | disclosed |