Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17242255 | 0.85 | MEN1 (0.53) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL23753577 | 0.84 | MEN1 (0.57) | MEN1KMT2ACYP3A4ALDH1A1TSHR | |
| SCHEMBL5697552 | 0.82 | MEN1 (0.59) | MEN1KMT2ACYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL28688992 | 0.81 | MEN1 (0.53) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL27646258 | 0.81 | CYP3A4 (0.56) | MEN1KMT2ACYP3A4ALDH1A1TSHR | |
| SCHEMBL5260935 | 0.79 | MEN1 (0.52) | MEN1KMT2ACHEK2KIF11 | |
| SCHEMBL23753572 | 0.79 | MCL1 (0.56) | MEN1KMT2AALDH1A1TDP1PKM | |
| SCHEMBL28476797 | 0.78 | THRB (0.44) | MEN1KMT2ACYP3A4ALDH1A1TSHR | |
| SCHEMBL29250971 | 0.77 | MEN1 (0.53) | MEN1KMT2ACYP3A4KIF11ESR1 | |
| SCHEMBL3644529 | 0.77 | KMT2A (0.53) | MEN1KMT2ACYP3A4ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117695280-A | Pyridin-2 (1H) -one quinolinone derivatives as mutant isocitrate dehydrogenase inhibitors | 福马治疗股份有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-111909130-B | Pyridin-2 (1H) -one quinolinone derivatives as mutant isocitrate dehydrogenase inhibitors | 福马治疗股份有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-111909130-A | Pyridin-2 (1H) -one quinolinone derivatives as mutant isocitrate dehydrogenase inhibitors | 福马治疗股份有限公司 | 2020-11-10 | — | — | CN | disclosed |
| CN-107001328-B | Pyridin-2 (1H) -one quinolinone derivatives as mutant isocitrate dehydrogenase inhibitors | 福马治疗股份有限公司 | 2020-06-05 | — | — | CN | disclosed |