Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 10/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27650204 | 0.86 | NR4A2 (0.65) | NR4A2FOLH1ALDH1A1NPSR1MRGPRX4 | |
| SCHEMBL25284732 | 0.84 | MRGPRX4 (0.56) | NR4A2FOLH1ALDH1A1NPSR1MRGPRX4 | |
| SCHEMBL6000790 | 0.83 | MRGPRX4 (0.68) | NR4A2FOLH1ALDH1A1NPSR1MRGPRX4 | |
| SCHEMBL11427053 | 0.82 | ALDH1A1 (0.57) | NR4A2FOLH1ALDH1A1NPSR1MRGPRX4 | |
| SCHEMBL30395109 | 0.81 | FOLH1 (0.66) | NR4A2FOLH1MRGPRX4KMT2A | |
| SCHEMBL1817886 | 0.81 | FOLH1 (0.66) | NR4A2FOLH1MRGPRX4KMT2A | |
| Bicarbonate SCHEMBL28004703 | 0.81 | TSHR (0.56) | ALDH1A1TP53RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3312463 | 0.81 | MRGPRX4 (0.60) | FOLH1ALDH1A1NPSR1MRGPRX4TP53 | |
| SCHEMBL371526 | 0.80 | FOLH1 (0.70) | NR4A2FOLH1MRGPRX4KMT2A | |
| SCHEMBL27832544 | 0.80 | MRGPRX4 (0.49) | NR4A2CYSLTR1FOLH1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1832928-B | 5-membered heterocycle-based p38 kinase inhibitors | NOVARTIS AG (CH) | 2012-07-04 | — | — | CN | disclosed |
| CN-1832928-A | 5-membered heterocycle-based p38 kinase inhibitors | NOVARTIS AG (CH) | 2006-09-13 | — | — | CN | disclosed |