Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Aniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aniline SCHEMBL10806060 | 0.98 | TSHR (0.52) | TSHRGAAALDH1A1NT5EPSIP1 | |
| Aniline SCHEMBL167327 | 0.88 | TSHR (0.65) | TSHRGAAALDH1A1NT5EKDM4E | |
| Aniline SCHEMBL676147 | 0.88 | TSHR (0.65) | TSHRGAAALDH1A1NT5EKDM4E | |
| Aniline SCHEMBL167326 | 0.88 | TSHR (0.65) | TSHRGAAALDH1A1NT5EKDM4E | |
| Aniline SCHEMBL28037884 | 0.85 | TSHR (0.61) | TSHRGAAALDH1A1NT5EKDM4E | |
| Aniline SCHEMBL5693986 | 0.85 | TSHR (0.61) | TSHRGAAALDH1A1NT5EKDM4E | |
| Aniline SCHEMBL7856690 | 0.85 | TSHR (0.44) | TSHRGAAALDH1A1NT5EKDM4E | |
| Aniline SCHEMBL8010474 | 0.85 | TSHR (0.44) | TSHRGAAALDH1A1NT5EPSIP1 | |
| Aniline SCHEMBL8022436 | 0.84 | TSHR (0.52) | TSHRGAAALDH1A1NT5EKDM4E | |
| Aniline SCHEMBL7863425 | 0.84 | TSHR (0.52) | TSHRGAAALDH1A1NT5EKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1810892-A | Novel reactive yellow dye compounds and mixture thereof | KYUNG IN SYNTHETIC CORP (KR) | 2006-08-02 | — | — | CN | disclosed |