Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Aniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aniline SCHEMBL167327 | 1.00 | TSHR (0.65) | TSHRALDH1A1NT5EHSD17B10TDP1 | |
| Aniline SCHEMBL167326 | 1.00 | TSHR (0.65) | TSHRALDH1A1NT5EHSD17B10TDP1 | |
| Aniline SCHEMBL5693986 | 0.97 | TSHR (0.61) | TSHRALDH1A1NT5EHSD17B10TDP1 | |
| Aniline SCHEMBL28037884 | 0.97 | TSHR (0.61) | TSHRALDH1A1NT5EHSD17B10TDP1 | |
| Aniline SCHEMBL28305697 | 0.95 | TSHR (0.58) | TSHRALDH1A1NT5EHSD17B10TDP1 | |
| Aniline SCHEMBL3156113 | 0.92 | TSHR (0.61) | TSHRALDH1A1NT5EHSD17B10TDP1 | |
| Aniline SCHEMBL7863425 | 0.90 | TSHR (0.52) | TSHRALDH1A1NT5EHSD17B10TDP1 | |
| Aniline SCHEMBL8022436 | 0.90 | TSHR (0.52) | TSHRALDH1A1NT5EHSD17B10TDP1 | |
| Aniline SCHEMBL3783271 | 0.89 | TSHR (0.58) | TSHRALDH1A1NT5EHSD17B10TDP1 | |
| Aniline SCHEMBL6026655 | 0.89 | TSHR (0.58) | TSHRALDH1A1NT5EHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968009-B2 | Electrically conductive nanocomposite particles having a polyalkyl acrylate core and a polyaniline coating | UPPA-UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR (FR) | 2011-06-28 | — | — | US | disclosed |
| US-20090212263-A1 | ELECTRICALLY CONDUCTIVE NANOCOMPOSITE PARTICLES HAVING A POLYALKYL ACRYLATE CORE AND A POLYANILINE COATING | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2009-08-27 | — | — | US | disclosed |
| US-4316993-A | Process for the preparation of 4-phenoxy-phenols | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-02-23 | — | — | US | disclosed |