Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.33 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.33 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.32 |
| ▸ | TOP2A | P11388 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27598186 | 1.00 | SLC6A1 (0.33) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL20617836 | 1.00 | SLC6A1 (0.33) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL27504346 | 0.89 | SLC6A1 (0.40) | SLC6A1SLC6A11SLC6A13CYP19A1 | |
| SCHEMBL27744409 | 0.89 | SLC6A1 (0.40) | SLC6A1SLC6A11SLC6A13CYP19A1 | |
| SCHEMBL27657052 | 0.89 | SLC6A1 (0.40) | SLC6A1SLC6A11SLC6A13CYP19A1 | |
| SCHEMBL914574 | 0.88 | CHRM3 (0.39) | GABRA5GABRB2GABRA1GABRA4CHRM3 | |
| SCHEMBL27908028 | 0.87 | CYP19A1 (0.38) | SLC6A1SLC6A11SLC6A13CHRM3CYP19A1 | |
| Hydrochloric Acid SCHEMBL28914966 | 0.86 | CHRM3 (0.38) | GABRA5GABRB2GABRA1GABRA4HSP90AB1 | |
| SCHEMBL48890 | 0.84 | CHRNB2 (0.32) | CYP19A1 | |
| SCHEMBL28111113 | 0.83 | CHRM3 (0.30) | CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109475566-A | Pharmaceutical composition and its purposes for treating cancer and autoimmune disease | 浙江导明医药科技有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-109328187-A | A kind of new compound and its preparation and application with FGFR inhibitory activity | 中国科学院上海药物研究所 | 2019-02-12 | — | — | CN | disclosed |
| CN-109096274-A | It can be used for treating the aryl-linking compound of human tumor, neurology and amynologic disease | 比奥根MA公司 | 2018-12-28 | — | — | CN | disclosed |
| CN-108947913-A | It can be used for treating the aryl-linking compound of human tumor, neurology and amynologic disease | 比奥根MA公司 | 2018-12-07 | — | — | CN | disclosed |
| CN-107428731-A | Substituted 2-hydro-pyrazole derivatives as anti-cancer agents | 正大天晴药业集团股份有限公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-107406454-A | Optimized drug combinations and their use for the treatment of cancer and autoimmune diseases | 浙江导明医药科技有限公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-106459002-A | Biaryl compounds useful in the treatment of human oncological, neurological and immunological diseases | 比奥根MA公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-103998042-B | Use of inhibitors of the activity or function of PI3K | 诺华股份有限公司 | 2016-12-28 | — | — | CN | disclosed |
| CN-103814021-B | Dihydroquinoline 2 ketone derivatives | 霍夫曼-拉罗奇有限公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-106146508-A | The drug combination optimized and treatment cancer and the purposes of autoimmune disease thereof | 浙江导明医药科技有限公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-100509798-C | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prevention and treatment of disorders related thereto | ARENA PHARM INC (US) | 2009-07-08 | — | — | CN | disclosed |
| CN-100480249-C | Pyrrolopyridine-2-carboxylic acid amides as glycogen phosphorylase inhibitors | PROSIDION LTD (GB) | 2009-04-22 | — | — | CN | disclosed |
| CN-101384583-A | Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments | SANOFI AVENTIS (FR) | 2009-03-11 | — | — | CN | disclosed |
| CN-101370501-A | Novel azacycly-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments | SANOFI AVENTIS (FR) | 2009-02-18 | — | — | CN | disclosed |
| CN-101362765-A | 5,7-diaminopyrazolo '4,3-d!pyrimidines with PDE-5 inhibiting activity | PFIZER (US) | 2009-02-11 | — | — | CN | disclosed |
| CN-101362764-A | 5,7-diaminopyrazolo '4,3-d!pyrimidines with PDE-5 inhibiting activity | PFIZER (US) | 2009-02-11 | — | — | CN | disclosed |
| CN-1930126-A | Pyridone Derivatives | BANYU PHARMA CO LTD (JP) | 2007-03-14 | — | — | CN | disclosed |
| CN-1882591-A | 5, 7-diaminopyrazolo [4, 3-d ] pyrimidines with PDE-5 inhibiting activity | PFIZER LTD (US) | 2006-12-20 | — | — | CN | disclosed |
| CN-1826340-A | Pyrrolopyridine-2-carboxylic acid amides as glycogen phosphorylase inhibitors | PROSIDION LTD (GB) | 2006-08-30 | — | — | CN | disclosed |
| CN-1823056-A | Trisubstituted aryl and heteroaryl derivatives as modulatorsof metabolism and the prophylaxis and treatment of disorders related thereto | ARENA PHARM INC (US) | 2006-08-23 | — | — | CN | disclosed |