Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10677990 | 0.80 | TAAR1 (0.50) | FLT3APPNFE2L2 | |
| SCHEMBL653095 | 0.77 | NFE2L2 (0.43) | APPPOLBNFE2L2TRPA1 | |
| SCHEMBL654529 | 0.74 | NFE2L2 (0.48) | APPNFE2L2TRPA1 | |
| SCHEMBL9201400 | 0.74 | TRPA1 (0.44) | APPNFE2L2TRPA1 | |
| SCHEMBL5878874 | 0.72 | TRPA1 (0.42) | NFE2L2TRPA1 | |
| SCHEMBL3650173 | 0.69 | TAAR1 (0.44) | NFE2L2 | |
| SCHEMBL1515183 | 0.69 | HSD11B1 (0.40) | NFE2L2TRPA1 | |
| SCHEMBL2153833 | 0.68 | NFE2L2 (0.44) | APPPOLBNFE2L2TRPA1 | |
| SCHEMBL5787295 | 0.68 | TAAR1 (0.50) | APPPOLBMPONFE2L2 | |
| SCHEMBL27572435 | 0.68 | NFE2L2 (0.42) | APPNFE2L2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101208093-A | Use of pyrazolyl-pyrimidine derivatives in the treatment of pain | ASTRAZENECA AB CLAESSON ALF (SE) | 2008-06-25 | — | — | CN | disclosed |
| CN-1905884-A | Pyrazole derivatives as inhibitors of receptor tyrosyne kinases | ASTRAZENECA AB (SE) | 2007-01-31 | — | — | CN | disclosed |