Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5710903 | 0.87 | ALDH1A1 (0.50) | LMNAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27655162 | 0.86 | LMNA (0.43) | LMNAMAPK1RAB9AKDM4EALDH1A1 | |
| SCHEMBL5710843 | 0.74 | HRH1 (0.49) | KDM4EALDH1A1GRM5 | |
| SCHEMBL2474221 | 0.71 | LMNA (0.76) | LMNAMAPK1RAB9AALDH1A1MEN1 | |
| SCHEMBL27675025 | 0.69 | RAB9A (0.56) | LMNAMAPK1RAB9AKDM4EALDH1A1 | |
| SCHEMBL25380612 | 0.69 | FFAR1 (0.38) | LMNARAB9AALDH1A1HTTMEN1 | |
| SCHEMBL17676107 | 0.68 | ALDH1A1 (0.46) | LMNAMAPK1RAB9AKDM4EALDH1A1 | |
| SCHEMBL21386081 | 0.68 | NFE2L2 (0.32) | RAB9ASMN1; SMN2MAPT | |
| SCHEMBL22462777 | 0.68 | KDM1A (0.37) | MEN1KMT2A | |
| SCHEMBL27664371 | 0.67 | MAPT (0.54) | LMNAMAPK1KDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1934097-A | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-03-21 | — | — | CN | claimed |
| CN-1934097-A | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-03-21 | — | — | CN | disclosed |