Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7504782 | 0.83 | ALDH1A1 (0.53) | ALDH1A1POLBHTT | |
| SCHEMBL13604258 | 0.82 | PSIP1 (0.46) | PSIP1HSD11B1ALDH1A1POLBMAPT | |
| SCHEMBL11407383 | 0.81 | HSD11B1 (0.56) | PSIP1HSD11B1ALDH1A1POLBMAPT | |
| SCHEMBL27747516 | 0.81 | NPC1 (0.51) | HSD11B1ALDH1A1POLBMAPTHTT | |
| SCHEMBL27658743 | 0.81 | POLB (0.48) | HSD11B1ALDH1A1POLB | |
| SCHEMBL12237322 | 0.81 | CA2 (0.53) | PSIP1HSD11B1ALDH1A1POLBMAPT | |
| SCHEMBL27987111 | 0.81 | PSIP1 (0.47) | PSIP1HSD11B1POLBMAPTL3MBTL1 | |
| SCHEMBL27678832 | 0.80 | HDAC3 (0.42) | ALDH1A1L3MBTL1 | |
| SCHEMBL27658595 | 0.80 | CYP1A2 (0.47) | — | |
| SCHEMBL27658684 | 0.80 | ATM (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1938273-B | Tetrahydrocarbazoles and derivatives | HOFFMAN-LA ROCHE LTD. (CH) | 2011-12-14 | — | — | CN | disclosed |
| CN-1938273-A | Tetrahydrocarbazoles and derivatives | HOFFMANN LA ROCHE (CH) | 2007-03-28 | — | — | CN | disclosed |