Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 4/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27900729 | 0.83 | TLR8 (0.47) | NOS2TLR8GABRPGABRDGABRA1 | |
| SCHEMBL27570675 | 0.81 | TYR (0.37) | NOS2TLR8GABRPGABRDGABRA1 | |
| SCHEMBL26489048 | 0.80 | NOS2 (0.44) | NOS2NOS3 | |
| SCHEMBL15528179 | 0.78 | NOS2 (0.49) | NOS2TLR8GABRPGABRDGABRA1 | |
| SCHEMBL25886999 | 0.77 | TLR8 (0.37) | NOS2TLR8GABRPGABRDGABRA1 | |
| Hexane SCHEMBL28173825 | 0.77 | NOS2 (0.52) | NOS2TLR8SKP2NOS3SMN1; SMN2 | |
| SCHEMBL21834060 | 0.76 | ALDH1A1 (0.37) | NOS2TLR8CA2 | |
| SCHEMBL11379212 | 0.76 | TYR (0.41) | NOS2TLR8TYRHTR2AHTR2C | |
| SCHEMBL840920 | 0.75 | TYR (0.48) | NOS2TLR8GABRPGABRDGABRA1 | |
| SCHEMBL8916740 | 0.75 | TLR8 (0.40) | NOS2TLR8HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1930144-A | 3-'4-heterocyclyl -1,2,3,-triazol-1-yl!-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases | BOEHRINGER INGELHEIM PHARMA (US) | 2007-03-14 | — | — | CN | disclosed |