Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | NSD2 | O96028 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | CTSB | P07858 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27707704 | 0.97 | MAPT (0.60) | KDM4EMEN1MAPTKMT2ANSD2 | |
| SCHEMBL29401731 | 0.77 | CASP6 (0.62) | KDM4EMEN1MAPTKMT2APOLB | |
| SCHEMBL458 | 0.77 | CASP6 (0.62) | KDM4EMEN1MAPTKMT2APOLB | |
| SCHEMBL26656853 | 0.76 | CTSB (0.58) | KDM4EMEN1MAPTKMT2ACTSB | |
| SCHEMBL10489198 | 0.75 | ALOX5 (0.50) | KDM4EMEN1MAPTKMT2ANSD2 | |
| SCHEMBL1740621 | 0.75 | CASP6 (0.61) | KDM4EMEN1MAPTKMT2APOLB | |
| SCHEMBL8483724 | 0.75 | CTSB (0.61) | KDM4EMEN1MAPTKMT2APOLB | |
| SCHEMBL1740623 | 0.75 | CASP6 (0.61) | KDM4EMEN1MAPTKMT2APOLB | |
| SCHEMBL11701285 | 0.74 | MAPT (0.72) | KDM4EMEN1MAPTKMT2APOLB | |
| SCHEMBL29904678 | 0.73 | MAPT (1.00) | KDM4EMEN1MAPTKMT2ANSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101357958-B | Supported vanadium oxide non-metallocene catalyst for polyethylene and preparation method | CHINA PETROCHEMICAL CORP | 2010-08-25 | — | — | CN | disclosed |
| CN-100460423-C | In-situ synthesized supported vanadium non-metallocene polyolefin catalyst and its prepn and application | CHINA PETROLEUM & CHEMICAL (CN) | 2009-02-11 | — | — | CN | disclosed |
| CN-100460424-C | Vanadium non-metallocene polyolefin catalyst and its prepn and application | CHINA PETROLEUM & CHEMICAL (CN) | 2009-02-11 | — | — | CN | disclosed |
| CN-101357958-A | Supported vanadium oxide non-metallocene catalyst for polyethylene and preparation method | CHINA PETROCHEMICAL CORP (CN) | 2009-02-04 | — | — | CN | disclosed |
| CN-1887920-A | Vanadium non-metallocene polyolefin catalyst and its prepn and application | CHINA PETROCHEMICAL CORP (CN) | 2007-01-03 | — | — | CN | disclosed |
| CN-1887919-A | In-situ synthesized supported vanadium non-metallocene polyolefin catalyst and its prepn and application | CHINA PETROCHEMICAL CORP (CN) | 2007-01-03 | — | — | CN | disclosed |