Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28758171 | 0.92 | ALDH1A1 (0.41) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL5035190 | 0.89 | MAPT (0.49) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL6488544 | 0.82 | ALDH1A1 (0.42) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL5034815 | 0.80 | KDM4E (0.43) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL5034980 | 0.79 | KDM4E (0.47) | MAPTRAB9AALDH1A1KDM4EHTT | |
| SCHEMBL5032543 | 0.79 | LMNA (0.48) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL5032531 | 0.78 | KDM4E (0.41) | MAPTRAB9AALDH1A1KDM4EHTT | |
| SCHEMBL5032616 | 0.78 | KDM4E (0.41) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| Propylamine SCHEMBL6488547 | 0.78 | KDM4E (0.46) | MAPTRAB9AALDH1A1KDM4EHTT | |
| Methylethylamine SCHEMBL6488540 | 0.78 | KDM4E (0.43) | RAB9AALDH1A1KDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | claimed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | claimed |
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |