Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTPRB | P23467 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5034980 | 0.92 | KDM4E (0.47) | KDM4ETP53ALDH1A1RAB9ASMN1; SMN2 | |
| Propylamine SCHEMBL6488547 | 0.90 | KDM4E (0.46) | KDM4ETP53ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5035889 | 0.90 | KDM4E (0.43) | KDM4ETP53ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5034815 | 0.84 | KDM4E (0.43) | KDM4ETP53ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5035190 | 0.83 | MAPT (0.49) | KDM4EALDH1A1RAB9ASMN1; SMN2HTT | |
| SCHEMBL5032520 | 0.82 | LMNA (0.47) | KDM4EALDH1A1RAB9ASMN1; SMN2HTT | |
| SCHEMBL5032531 | 0.82 | KDM4E (0.41) | KDM4ETP53ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5032616 | 0.82 | KDM4E (0.41) | KDM4ETP53ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5034975 | 0.82 | KDM4E (0.44) | KDM4ETP53ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5032555 | 0.81 | ALDH1A1 (0.44) | KDM4ETP53ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050153962-A1 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153962-A1 | Thiazole derivatives | CNR1, CNR2, GPR119 | KDM4E 3200/4885TP53 4500/4885ALDH1A1 473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.