Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | THRA | P10827 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28275326 | 0.82 | ESR1 (0.52) | ESR1ESR2TAAR1SLC6A2THRA | |
| SCHEMBL282437 | 0.81 | THRB (0.50) | ESR1ESR2ADRA2AADRA2BADRA2C | |
| SCHEMBL27713169 | 0.81 | HSD17B10 (0.48) | ESR1ESR2THRATHRBCA1 | |
| SCHEMBL283411 | 0.80 | THRB (0.49) | ADRA2AADRA2BADRA2CMEN1MAPT | |
| SCHEMBL11951604 | 0.79 | ADRA2A (0.55) | ESR1ESR2ADRA2AADRA2BADRA2C | |
| SCHEMBL12305567 | 0.78 | CYP4F2 (0.46) | ADRA2AADRA2BADRA2CPTGS1PTGS2 | |
| SCHEMBL19002432 | 0.78 | PNMT (0.46) | TAAR1SLC6A2 | |
| SCHEMBL27666344 | 0.78 | KEAP1 (0.49) | TAAR1MEN1MAPTKMT2APTGS1 | |
| SCHEMBL21377275 | 0.77 | ESR1 (0.38) | ESR1ESR2PTGS1PTGS2THRA | |
| SCHEMBL8205756 | 0.76 | CYP1A2 (0.42) | ADRA2AADRA2BADRA2CTAAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1882327-A | Novel phosphorus-containing thyromimetics | METABASIS THERAPEUTICS INC (US) | 2006-12-20 | — | — | CN | disclosed |