Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.71 |
| ▸ | CTSK | P43235 | 7/20 | 0.60 |
| ▸ | CTSS | P25774 | 4/20 | 0.60 |
| ▸ | CTSB | P07858 | 2/20 | 0.60 |
| ▸ | CTSL | P07711 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.51 |
| ▸ | REN | P00797 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323726 | 0.90 | ACE (0.71) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL1791039 | 0.87 | ACE (0.78) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL7326335 | 0.87 | ACE (0.78) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL2603668 | 0.87 | ACE (0.70) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL9262578 | 0.86 | ACE (0.65) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL1790253 | 0.84 | ACE (0.70) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL6516027 | 0.84 | ACE (0.70) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL17688687 | 0.84 | ACE (0.70) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL10536264 | 0.84 | ACE (0.70) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL8271187 | 0.84 | CTSK (0.59) | ACECTSKCTSSCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100537523-C | Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease | MERCK & CO INC (US) | 2009-09-09 | — | — | CN | disclosed |
| CN-1898199-A | Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease | MERCK & CO INC (US) | 2007-01-17 | — | — | CN | disclosed |