Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | MELK | Q14680 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 4/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27649567 | 0.84 | PIK3R2 (0.48) | HTR1AADRA2ACHRM1DRD1SLC6A4 | |
| SCHEMBL27669648 | 0.83 | HTR6 (0.44) | HTR1AADRA2ACHRM1DRD1SLC6A4 | |
| SCHEMBL4752873 | 0.83 | MELK (0.46) | HTR1AADRA2ACHRM1DRD1SLC6A4 | |
| SCHEMBL27649849 | 0.81 | MELK (0.46) | MELKHTR6JAK2AURKAAURKB | |
| SCHEMBL27669696 | 0.80 | HRH3 (0.46) | HTR1AADRA2ACHRM1DRD1SLC6A4 | |
| SCHEMBL4116250 | 0.72 | L3MBTL1 (0.65) | GAA | |
| SCHEMBL27741325 | 0.72 | MAPK10 (0.46) | GAA | |
| SCHEMBL27649623 | 0.71 | ADRA2C (0.50) | MELKJAK2AURKAGAAGFER | |
| SCHEMBL2383528 | 0.70 | HRH4 (0.60) | HTR1AJAK2HRH4GAAMAPKAPK2 | |
| SCHEMBL1384498 | 0.69 | KCNH2 (0.65) | HTR1ASLC6A4KCNH2HTR6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | claimed |
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | disclosed |