Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27649623 | 0.88 | ADRA2C (0.50) | JAK2MAPKAPK2MELKADORA1GAA | |
| SCHEMBL27669759 | 0.83 | HTR1A (0.50) | HTR6JAK2HRH4JAK1TYK2 | |
| SCHEMBL27669767 | 0.83 | ADRA2C (0.50) | JAK2MAPKAPK2MELKADORA1GAA | |
| SCHEMBL27649425 | 0.81 | ALDH1A1 (0.54) | HTR6JAK2MAPKAPK2BRD4KCNH2 | |
| SCHEMBL4015250 | 0.81 | ADRA2C (0.49) | JAK2HRH4MELKADORA1GAA | |
| SCHEMBL27649461 | 0.80 | KDM4E (0.48) | HTR6HRH4GAAKDM4ENPC1 | |
| SCHEMBL27649645 | 0.77 | AURKA (0.43) | HTR6JAK2MELKADORA1GAA | |
| SCHEMBL27669721 | 0.76 | MAP4K1 (0.49) | HTR6JAK2JAK3BRD4DRD3 | |
| SCHEMBL2383528 | 0.73 | HRH4 (0.60) | JAK2HRH4MAPKAPK2ADORA1ADORA3 | |
| SCHEMBL27649830 | 0.72 | HTR6 (0.45) | HTR6HRH4MELKHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | claimed |
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | disclosed |