Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2765957 | 0.97 | CHRNB2 (0.47) | KDM4EGFERP2RX7PTGER2TGFBR1 | |
| SCHEMBL2763745 | 0.88 | BCHE (0.49) | TGFBR1ACVR1DRD2DRD4DRD3 | |
| SCHEMBL2764448 | 0.87 | P2RX7 (0.47) | KDM4EP2RX7PTK2SLC16A3MEN1 | |
| SCHEMBL2764588 | 0.87 | P2RX7 (0.47) | KDM4EP2RX7PTGER2PTK2SLC16A3 | |
| SCHEMBL2766860 | 0.84 | SLC29A1 (0.50) | KDM4ETGFBR1ACVR1DRD2DRD4 | |
| SCHEMBL2766026 | 0.79 | KDM4E (0.45) | KDM4ETGFBR1ACVR1MEN1ALDH1A1 | |
| SCHEMBL2766041 | 0.76 | TDP1 (0.48) | KDM4EP2RX7SLC16A3MEN1ALDH1A1 | |
| SCHEMBL2765235 | 0.76 | TGFBR1 (0.45) | KDM4ETGFBR1ACVR1DRD2DRD4 | |
| SCHEMBL2764396 | 0.76 | KDM4E (0.49) | KDM4ETGFBR1ACVR1MEN1ALDH1A1 | |
| SCHEMBL2764392 | 0.74 | PDE4A (0.47) | KDM4ESLC16A3MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400515-B1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | KOWA CO (JP) | 2010-04-14 | — | — | EP | disclosed |
| EP-1400515-A1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6472386-B1 | Cyclic diamine compound with 5-membered ring groups | KOWA CO., LTD. (JP) | 2002-10-29 | — | — | US | disclosed |