Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MARS1 | P56192 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2765141 | 0.89 | TDP1 (0.54) | TDP1ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL12336607 | 0.86 | MARS1 (0.54) | TDP1MARS1P2RX7ALDH1A1POLB | |
| SCHEMBL2764448 | 0.80 | P2RX7 (0.47) | MARS1P2RX7ALDH1A1KDM4EPOLB | |
| SCHEMBL2763959 | 0.80 | TDP1 (0.47) | TDP1ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL2764588 | 0.78 | P2RX7 (0.47) | MARS1P2RX7ALDH1A1KDM4EPOLB | |
| SCHEMBL2767259 | 0.76 | KDM4E (0.48) | P2RX7ALDH1A1KDM4ETSHRHSD17B10 | |
| SCHEMBL2763992 | 0.76 | TDP1 (0.50) | TDP1ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL2227637 | 0.75 | SMN1; SMN2 (0.64) | TDP1MARS1ALDH1A1POLBFAAH | |
| SCHEMBL2765957 | 0.74 | CHRNB2 (0.47) | P2RX7ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL17375118 | 0.71 | FAAH (0.52) | ALDH1A1KDM4EPOLBHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400515-B1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | KOWA CO (JP) | 2010-04-14 | — | — | EP | disclosed |
| EP-1400515-A1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6472386-B1 | Cyclic diamine compound with 5-membered ring groups | KOWA CO., LTD. (JP) | 2002-10-29 | — | — | US | disclosed |