Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693551 | 0.88 | NPC1 (0.49) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL27693499 | 0.86 | CHRM1 (0.47) | KMT2AMEN1MAPTCHRM1HPGD | |
| SCHEMBL27693514 | 0.86 | KMT2A (0.47) | KMT2AMEN1RXFP1MAPTTP53 | |
| SCHEMBL27675310 | 0.85 | CHRM1 (0.54) | KMT2AMEN1MAPTCHRM1LMNA | |
| SCHEMBL27693645 | 0.85 | CHRM1 (0.54) | KMT2AMEN1MAPTALDH1A1NPC1 | |
| SCHEMBL27693487 | 0.85 | LMNA (0.51) | KMT2AMEN1ALDH1A1CHRM1HPGD | |
| SCHEMBL27675112 | 0.85 | TSHR (0.48) | KMT2AMAPTTP53ALDH1A1CHRM1 | |
| SCHEMBL27693452 | 0.84 | CHRM1 (0.49) | KMT2AMEN1RXFP1MAPTTP53 | |
| SCHEMBL27693526 | 0.83 | ALDH1A1 (0.48) | KMT2AMEN1MAPTALDH1A1CHRM1 | |
| SCHEMBL28766931 | 0.82 | CHRM1 (0.52) | KMT2AMEN1MAPTNPC1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |