Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 6/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 6/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28766931 | 0.85 | CHRM1 (0.52) | CHRM1LMNAMAOBKDM4E | |
| SCHEMBL27693500 | 0.84 | CHRM1 (0.41) | CHRM1LMNAMAOBKDM4E | |
| SCHEMBL27675094 | 0.84 | TRPV1 (0.45) | CHRM1LMNAKDM4E | |
| SCHEMBL27693487 | 0.83 | LMNA (0.51) | CHRM1LMNAMAOBKDM4EALDH1A1 | |
| SCHEMBL27675384 | 0.82 | CHRM1 (0.49) | CHRM1LMNAMAOBKDM4EALDH1A1 | |
| SCHEMBL27675247 | 0.82 | NPC1 (0.47) | CHRM1LMNAKDM4EALDH1A1 | |
| SCHEMBL27675121 | 0.80 | CHRM1 (0.47) | CHRM1LMNAKDM4E | |
| SCHEMBL27693452 | 0.80 | CHRM1 (0.49) | CHRM1LMNAMAOBKDM4E | |
| SCHEMBL27675102 | 0.80 | LMNA (0.44) | LMNAALDH1A1 | |
| SCHEMBL27693534 | 0.80 | MAOB (0.50) | CHRM1LMNAMAOBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |