Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693487 | 0.91 | LMNA (0.51) | CHRM1LMNAKDM4EHTR6 | |
| SCHEMBL27675247 | 0.87 | NPC1 (0.47) | CHRM1LMNAKDM4ENPC1RAB9A | |
| SCHEMBL27693452 | 0.85 | CHRM1 (0.49) | CHRM1LMNAKDM4EHTR6NPC1 | |
| SCHEMBL27675384 | 0.85 | CHRM1 (0.49) | CHRM1LMNAKDM4EHTR6 | |
| SCHEMBL28766931 | 0.85 | CHRM1 (0.52) | CHRM1LMNAKDM4EHTR6NPC1 | |
| SCHEMBL27675219 | 0.84 | MAOB (0.48) | CHRM1LMNAKDM4ENPC1RAB9A | |
| SCHEMBL27675213 | 0.84 | HTT (0.46) | CHRM1LMNAKDM4EHTR6CAPN1 | |
| SCHEMBL27675257 | 0.83 | CHRM1 (0.55) | CHRM1LMNAKDM4E | |
| SCHEMBL27693499 | 0.83 | CHRM1 (0.47) | CHRM1LMNAKDM4E | |
| SCHEMBL28766934 | 0.82 | CFTR (0.48) | CHRM1LMNAKDM4EHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |