Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693487 | 0.88 | LMNA (0.51) | HSD17B10LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL27675121 | 0.87 | CHRM1 (0.47) | NPC1RAB9ALMNAKDM4ECHRM1 | |
| SCHEMBL27675146 | 0.82 | KCNQ3 (0.47) | LMNAKDM4EALDH1A1CHRM1 | |
| SCHEMBL27693567 | 0.80 | CREBBP (0.47) | LMNAKDM4EALDH1A1CHRM1GRIK1 | |
| SCHEMBL28766931 | 0.80 | CHRM1 (0.52) | NPC1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL27675384 | 0.80 | CHRM1 (0.49) | HSD17B10GRIN2BLMNASMN1; SMN2KDM4E | |
| SCHEMBL27693452 | 0.80 | CHRM1 (0.49) | NPC1NAMPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL27675227 | 0.79 | CFTR (0.48) | LMNASMN1; SMN2KDM4EALDH1A1CHRM1 | |
| SCHEMBL27675196 | 0.79 | CREBBP (0.52) | RAB9ALMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL27693586 | 0.79 | MAOB (0.60) | NPC1RAB9AGRIN2BLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |