Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 12/20 | 0.49 |
| ▸ | CA2 | P00918 | 12/20 | 0.49 |
| ▸ | CA12 | O43570 | 11/20 | 0.49 |
| ▸ | CA5A | P35218 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 2/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 10/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693468 | 0.90 | NAMPT (0.48) | MAPTCHRM1LMNA | |
| SCHEMBL27675089 | 0.88 | CA1 (0.51) | CA1CA2CA12CA4CA9 | |
| SCHEMBL27693487 | 0.87 | LMNA (0.51) | MAOBHTTCHRM1POLBLMNA | |
| SCHEMBL28766931 | 0.83 | CHRM1 (0.52) | MAOBMAPTCHRM1GAAPOLB | |
| SCHEMBL27675384 | 0.83 | CHRM1 (0.49) | MAOBHTTNPSR1CHRM1LMNA | |
| SCHEMBL27693452 | 0.83 | CHRM1 (0.49) | MAOBMAPTHTTCHRM1LMNA | |
| SCHEMBL27675205 | 0.82 | KDM4E (0.47) | CA1CA2CA12CA9HTT | |
| SCHEMBL27693499 | 0.81 | CHRM1 (0.47) | CA1CA2CA12CA9MAPT | |
| SCHEMBL27675257 | 0.81 | CHRM1 (0.55) | NPSR1CHRM1LMNA | |
| SCHEMBL27675121 | 0.81 | CHRM1 (0.47) | CHRM1JAK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |