Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1523174 | 0.83 | ALDH1A1 (0.67) | MAPTLMNAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL3481205 | 0.80 | TSHR (0.64) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL3683272 | 0.80 | TSHR (0.80) | MAPTLMNAALDH1A1TSHRMEN1 | |
| SCHEMBL29617021 | 0.80 | TSHR (0.80) | MAPTLMNAALDH1A1TSHRMEN1 | |
| SCHEMBL1611630 | 0.79 | ALDH1A1 (0.55) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL11464655 | 0.79 | ALDH1A1 (0.57) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6672572 | 0.79 | TSHR (0.57) | MAPTLMNAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL7984053 | 0.79 | ALDH1A1 (0.50) | MAPTLMNAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL27675217 | 0.78 | ALDH1A1 (0.50) | MAPTLMNAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL8991983 | 0.78 | ALDH1A1 (0.54) | MAPTLMNAHTTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |