Sugi Predict

Sugi Predict / Compounds / SCHEMBL2767536

SCHEMBL2767536

SCHEMBL2767536

[CH]1CCCCC1OCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PSEN1 P49768 1/20 0.40
▸ PSEN2 P49810 1/20 0.40
▸ APH1B Q8WW43 1/20 0.40
▸ NCSTN Q92542 1/20 0.40
▸ APH1A Q96BI3 1/20 0.40
▸ PSENEN Q9NZ42 1/20 0.40
▸ CTSL P07711 1/20 0.39
▸ CTSB P07858 1/20 0.39
▸ CTSK P43235 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ OPRM1 P35372 2/20 0.39
▸ OPRL1 P41146 2/20 0.39
▸ DPP4 P27487 1/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ SGMS2 Q8NHU3 1/20 0.38
▸ FOXM1 Q08050 1/20 0.38
▸ TMEM97 Q5BJF2 1/20 0.37
▸ CARM1 Q86X55 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12077141 1.00 PSEN1 (0.40) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL4440940 1.00 PSEN1 (0.40) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL10955709 0.98 CTSL (0.41) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL1061761 0.95 PSEN1 (0.41) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL1857531 0.95 PSEN1 (0.41) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL1066978 0.95 PSEN1 (0.41) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL15748046 0.81 CTSL (0.40) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL355570 0.79 OPRM1 (0.56) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2126154 0.77 PSEN1 (0.39) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL61112 0.77 CTSL (0.56) PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101712594-B 2-cyclohexyl-5-(1,1- dimethyl octyl) phenol and synthesizing method thereof WUHAN CATALIBI UNI PHARMA CO LTD 2013-02-13 — — CN claimed
CN-101712594-A 2-cyclohexyl-5-(1,1- dimethyl octyl) phenol and synthesizing method thereof WUHAN CATALIBI UNI PHARMA CO L 2010-05-26 — — CN claimed
EP-1855696-B1 9A-CARBAMOYL-Y-AMINOPROPYL- AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY GLAXOSMITHKLINE ZAGREB (HR) 2010-04-28 — — EP claimed
US-20090227601-A1 Bradykinin 1 Receptor Antagonists AMGEN INC. (US) 2009-09-10 — — US claimed
EP-1963285-A1 BRADYKININ 1 RECEPTOR ANTAGONISTS Amgen Inc. (US) 2008-09-03 — — EP claimed
US-20080200404-A1 Novel Antimalarial 9A-Carbamoyl-Aminoalkyl and 9A-Thiocarbamoyl-Aminoalkyl Azalides GLAXOSMITHKLINE ISTRAZIVACKI CENTER ZAGREB D.O.O (HR) 2008-08-21 — — US claimed
EP-1855696-A2 9A-CARBAMOYL-Y-AMINOPROPYL- AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) 2007-11-21 — — EP claimed
WO-2007067629-A1 BRADYKININ 1 RECEPTOR ANTAGONISTS AMGEN INC. (US) 2007-06-14 — — WO claimed
WO-2006085228-A2 9A-CARBAMOYL-Y-AMINOPROPYL AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (GB) 2006-08-17 — — WO claimed
CN-101712594-B 2-cyclohexyl-5-(1,1- dimethyl octyl) phenol and synthesizing method thereof WUHAN CATALIBI UNI PHARMA CO LTD 2013-02-13 — — CN disclosed
CN-101712594-B 2-cyclohexyl-5-(1,1- dimethyl octyl) phenol and synthesizing method thereof WUHAN CATALIBI UNI PHARMA CO LTD 2013-02-13 — — CN disclosed
CN-101712594-A 2-cyclohexyl-5-(1,1- dimethyl octyl) phenol and synthesizing method thereof WUHAN CATALIBI UNI PHARMA CO L 2010-05-26 — — CN disclosed
CN-101712594-A 2-cyclohexyl-5-(1,1- dimethyl octyl) phenol and synthesizing method thereof WUHAN CATALIBI UNI PHARMA CO L 2010-05-26 — — CN disclosed
EP-1855696-B1 9A-CARBAMOYL-Y-AMINOPROPYL- AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY GLAXOSMITHKLINE ZAGREB (HR) 2010-04-28 — — EP disclosed
CN-1293674-A Triazolo gerivatives and chemokine inhibitors containing the same as the active ingredient TORAY INDUSTRIES (JP) 2001-05-02 — — CN disclosed
EP-1067130-A1 TRIAZOLO DERIVATIVES AND CHEMOKINE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT TORAY INDUSTRIES, INC. (JP) 2001-01-10 — — EP disclosed
CN-1276778-A Biphenyl-5-alkanoic acid derivs. and use thereof ASAHI CHEMICAL IND (JP) 2000-12-13 — — CN disclosed
EP-1000937-A1 PROCESS FOR PRODUCING 4-ALKOXYCARBONYL-2-OXAZOLIDINONE COMPOUNDS UBE INDUSTRIES LIMITED (JP) 2000-05-17 — — EP disclosed
US-6020496-A 5-alkoxy-2(3H)-oxazolone compounds and process for preparing the same UBE INDUSTRIES, LTD. (JP) 2000-02-01 — — US disclosed
EP-0945448-A1 5-ALKOXY-2(3H)-OXAZOLONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF UBE INDUSTRIES, LTD. (JP) 1999-09-29 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090227601-A1 Bradykinin 1 Receptor Antagonists BDKRB1, BDKRB2, VIPR1 PSEN1 584/4885PSEN2 1226/4885APH1B 1423/4885
US-20080200404-A1 Novel Antimalarial 9A-Carbamoyl-Aminoalkyl and 9A-Thiocarbamoyl-Aminoalkyl Azalides DCTD, DHODH, DHRS9 PSEN1 4823/4885PSEN2 4857/4885APH1B 118/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.