Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 7/20 | 0.43 |
| ▸ | MMP1 | P03956 | 7/20 | 0.43 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP3 | P08254 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693820 | 1.00 | MMP9 (0.43) | MMP9MMP1MMP2MMP3MMP8 | |
| SCHEMBL27675438 | 1.00 | MMP9 (0.43) | MMP9MMP1MMP2MMP3MMP8 | |
| SCHEMBL27675463 | 0.93 | MMP1 (0.46) | MMP9MMP1MMP2MMP3MMP14 | |
| SCHEMBL27675486 | 0.93 | MMP1 (0.46) | MMP9MMP1MMP2MMP3MMP14 | |
| SCHEMBL14427240 | 0.87 | MMP8 (0.43) | MMP9MMP1MMP2MMP3MMP8 | |
| SCHEMBL14427239 | 0.84 | MMP1 (0.51) | MMP9MMP1MMP2MMP3MMP8 | |
| SCHEMBL5164149 | 0.83 | MMP1 (0.45) | MMP9MMP1MMP2MMP3MMP8 | |
| SCHEMBL5188709 | 0.83 | MMP1 (0.45) | MMP9MMP1MMP2MMP3MMP8 | |
| SCHEMBL5160889 | 0.83 | MMP1 (0.45) | MMP9MMP1MMP2MMP3MMP8 | |
| SCHEMBL5437193 | 0.82 | MMP8 (0.41) | MMP9MMP1MMP2MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006059-A | Substituted tetrahydroisoquinolines for use as MMP inhibitors, method for the production thereof, and use thereof in the form of medicaments | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-07-25 | — | — | CN | disclosed |