Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.46 |
| ▸ | MMP3 | P08254 | 5/20 | 0.43 |
| ▸ | MMP9 | P14780 | 5/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP7 | P09237 | 3/20 | 0.42 |
| ▸ | MMP13 | P45452 | 6/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27675486 | 1.00 | MMP1 (0.46) | MMP1ADAM17MMP3MMP9MMP2 | |
| SCHEMBL27675438 | 0.93 | MMP9 (0.43) | MMP1ADAM17MMP3MMP9MMP2 | |
| SCHEMBL27675460 | 0.93 | MMP9 (0.43) | MMP1ADAM17MMP3MMP9MMP2 | |
| SCHEMBL27693820 | 0.93 | MMP9 (0.43) | MMP1ADAM17MMP3MMP9MMP2 | |
| SCHEMBL14427249 | 0.86 | MMP1 (0.43) | MMP1ADAM17MMP3MMP9MMP2 | |
| SCHEMBL14427247 | 0.84 | MMP2 (0.52) | MMP1ADAM17MMP3MMP9MMP2 | |
| SCHEMBL5164121 | 0.82 | MMP1 (0.46) | MMP1ADAM17MMP3MMP9MMP2 | |
| SCHEMBL5160057 | 0.82 | MMP1 (0.46) | MMP1ADAM17MMP3MMP9MMP2 | |
| SCHEMBL5161051 | 0.82 | MMP1 (0.46) | MMP1ADAM17MMP3MMP9MMP2 | |
| SCHEMBL5439717 | 0.82 | MMP1 (0.41) | MMP1ADAM17MMP3MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006059-A | Substituted tetrahydroisoquinolines for use as MMP inhibitors, method for the production thereof, and use thereof in the form of medicaments | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-07-25 | — | — | CN | disclosed |