Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL27675445 | 0.77 | AKR1C3 (0.61) | MAPTKMT2AMEN1MMP8MMP3 | |
| SCHEMBL14427240 | 0.75 | MMP8 (0.43) | MAPTFAAHMGLLLMNAMMP8 | |
| SCHEMBL5435633 | 0.75 | MMP8 (0.41) | MAPTFAAHMGLLPOLBMMP8 | |
| SCHEMBL5437193 | 0.75 | MMP8 (0.41) | MAPTFAAHMGLLPOLBMMP8 | |
| SCHEMBL5439634 | 0.75 | MMP8 (0.41) | MAPTFAAHMGLLPOLBMMP8 | |
| SCHEMBL27675438 | 0.74 | MMP9 (0.43) | MAPTMMP8MMP3BCL2L1MCL1 | |
| SCHEMBL27693820 | 0.74 | MMP9 (0.43) | MAPTMMP8MMP3BCL2L1MCL1 | |
| SCHEMBL27675460 | 0.74 | MMP9 (0.43) | MAPTMMP8MMP3BCL2L1MCL1 | |
| SCHEMBL14427239 | 0.71 | MMP1 (0.51) | MMP8MMP3 | |
| Carbamic Acid SCHEMBL27693832 | 0.70 | KMT2A (0.73) | MAPTKMT2AMEN1PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006059-A | Substituted tetrahydroisoquinolines for use as MMP inhibitors, method for the production thereof, and use thereof in the form of medicaments | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-07-25 | — | — | CN | disclosed |