Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | MMP15 | P51511 | 2/20 | 0.41 |
| ▸ | MMP16 | P51512 | 2/20 | 0.41 |
| ▸ | MMP26 | Q9NRE1 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28763110 | 0.89 | MMP1 (0.51) | MMP1SMN1; SMN2ALDH1A1NPSR1MMP2 | |
| SCHEMBL5165124 | 0.85 | MMP1 (0.47) | MMP1NPC1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL5443030 | 0.84 | SMN1; SMN2 (0.44) | MMP1NPC1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL27675444 | 0.81 | MMP8 (0.53) | MMP1HTTMMP2MMP9MMP12 | |
| SCHEMBL27675439 | 0.78 | MMP1 (0.46) | MMP1SMN1; SMN2ALDH1A1MMP2MMP7 | |
| Carbamic Acid SCHEMBL27675490 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1RAB9AHPGDHTT | |
| SCHEMBL27693831 | 0.77 | THRB (0.52) | MMP1SMN1; SMN2MMP2MMP7MMP9 | |
| SCHEMBL5165066 | 0.75 | MMP1 (0.47) | MMP1SMN1; SMN2MMP2MMP7MMP9 | |
| SCHEMBL5164993 | 0.75 | MMP1 (0.47) | MMP1SMN1; SMN2MMP2MMP7MMP9 | |
| SCHEMBL5437137 | 0.74 | LMNA (0.44) | MMP1NPC1SMN1; SMN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006059-A | Substituted tetrahydroisoquinolines for use as MMP inhibitors, method for the production thereof, and use thereof in the form of medicaments | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-07-25 | — | — | CN | disclosed |