Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 4/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755300 | 0.87 | CYP1A2 (0.58) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL10860742 | 0.80 | CYP1A2 (0.58) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL27676384 | 0.80 | KDM4E (0.42) | CYP1A2CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL10860985 | 0.77 | DPP4 (0.46) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL10766797 | 0.77 | ALDH1A1 (0.41) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL11022918 | 0.77 | DPP4 (0.50) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL6567240 | 0.77 | MAPT (0.45) | ALOX15CYP2C19CPB1CES2CES1 | |
| SCHEMBL27676387 | 0.76 | PTGS2 (0.48) | CYP2D6CYP2C19KCNH2 | |
| SCHEMBL9422341 | 0.74 | MGLL (0.38) | ALOX15CPB1HTR2AMEN1KMT2A | |
| SCHEMBL10621528 | 0.74 | DPP4 (0.49) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1902172-A | N-acylated-3- (benzoyl) - pyrrolidines as 11-beta-hsd1 inhibitors useful for the treatment of metabolic disorders | ASTRAZENECA AB (SE) | 2007-01-24 | — | — | CN | claimed |
| CN-1902172-A | N-acylated-3- (benzoyl) - pyrrolidines as 11-beta-hsd1 inhibitors useful for the treatment of metabolic disorders | ASTRAZENECA AB (SE) | 2007-01-24 | — | — | CN | disclosed |