Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28750284 | 0.77 | ACHE (0.41) | GSK3BSMN1; SMN2ALOX5PKMKMT2A | |
| SCHEMBL5281555 | 0.74 | ALOX5 (0.42) | GSK3BSMN1; SMN2ALOX5PKML3MBTL1 | |
| SCHEMBL9351950 | 0.73 | GSK3B (0.41) | GSK3BSMN1; SMN2ALOX5PKMKMT2A | |
| SCHEMBL27673491 | 0.71 | LMNA (0.42) | GSK3BSMN1; SMN2ALOX5PKMKDM4E | |
| SCHEMBL4775710 | 0.70 | GSK3B (0.43) | GSK3BSMN1; SMN2ALOX5PKMKMT2A | |
| SCHEMBL1158351 | 0.70 | ALOX5 (0.42) | GSK3BSMN1; SMN2ALOX5PKMKMT2A | |
| SCHEMBL10804734 | 0.68 | HPGD (0.41) | GSK3BSMN1; SMN2ALOX5PKMKMT2A | |
| SCHEMBL647119 | 0.66 | ELANE (0.39) | GSK3BSMN1; SMN2ALOX5PKMKMT2A | |
| SCHEMBL5285647 | 0.66 | ALOX5 (0.40) | GSK3BSMN1; SMN2ALOX5KMT2AMEN1 | |
| SCHEMBL7474542 | 0.65 | TSHR (0.38) | KMT2AMEN1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1956971-A | Novel fused heterocycles and application thereof | ASTRAZENECA AB (SE) | 2007-05-02 | — | — | CN | disclosed |