Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | CCR1 | P32246 | 3/20 | 0.34 |
| ▸ | CCR5 | P51681 | 3/20 | 0.34 |
| ▸ | CCR8 | P51685 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27639614 | 0.75 | ADRA2A (0.41) | TP53TSHRCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27251616 | 0.70 | CCR1 (0.54) | KDM4EMAPTTP53LMNASMN1; SMN2 | |
| SCHEMBL27676438 | 0.69 | DAO (0.34) | — | |
| SCHEMBL3753757 | 0.68 | MAPT (0.41) | KDM4EMAPTTP53LMNASMN1; SMN2 | |
| SCHEMBL3745393 | 0.66 | LMNA (0.41) | KDM4EMAPTTP53LMNASMN1; SMN2 | |
| SCHEMBL27703143 | 0.66 | MAPK1 (0.36) | KDM4EMAPTTP53LMNASMN1; SMN2 | |
| SCHEMBL27676600 | 0.64 | IDO1 (0.34) | — | |
| SCHEMBL8404537 | 0.60 | LMNA (0.68) | KDM4EMAPTTP53LMNASMN1; SMN2 | |
| SCHEMBL13052937 | 0.60 | PSMD14 (0.38) | KDM4EMAPTTP53LMNASMN1; SMN2 | |
| SCHEMBL11973721 | 0.59 | LMNA (0.59) | KDM4EMAPTTP53LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101052638-B | As α24- (condensed cyclomethyl) -imidazole-2-thiones as adrenergic agonists | ALLERGAN INC | 2011-01-19 | — | — | CN | disclosed |
| CN-101052638-A | As α24- (condensed cyclomethyl) adrenergic agonists-imidazole-2-thiones | ALLERGAN INC (US) | 2007-10-10 | — | — | CN | disclosed |