Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3182059 | 0.85 | RAB9A (0.49) | MEN1RAB9AKMT2A | |
| SCHEMBL22014536 | 0.84 | TACR1 (0.48) | TACR1OPRD1OPRK1TSHRALOX15 | |
| SCHEMBL25295847 | 0.84 | P2RX3 (0.42) | TACR1OPRD1OPRK1TSHRALOX15 | |
| SCHEMBL22770414 | 0.82 | POLB (0.46) | OPRD1OPRK1MEN1RAB9AKMT2A | |
| SCHEMBL25301984 | 0.82 | POLB (0.43) | OPRD1OPRK1RAB9AGPR119PKM | |
| SCHEMBL28528706 | 0.78 | P2RX7 (0.43) | TACR1GPR119PKM | |
| SCHEMBL28986539 | 0.78 | USP2 (0.45) | TACR1OPRD1OPRK1PKM | |
| SCHEMBL963907 | 0.78 | USP2 (0.47) | TSHRMEN1KMT2APKM | |
| SCHEMBL20608062 | 0.77 | USP30 (0.41) | TACR1OPRD1OPRK1USP30TSHR | |
| SCHEMBL28974232 | 0.77 | NAMPT (0.54) | OPRD1OPRK1MEN1KMT2AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101072771-B | Cgrp receptor antagonists | MERCK & CO INC | 2010-09-29 | — | — | CN | disclosed |
| CN-101072771-A | Cgrp receptor antagonists | MERCK & CO INC (US) | 2007-11-14 | — | — | CN | disclosed |