Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | MAPT | P10636 | 3/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | RAB9A | P51151 | 7/20 | 0.76 |
| ▸ | SCD | O00767 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.63 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | RECQL | P46063 | 2/20 | 0.58 |
| ▸ | MGAM | O43451 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SI | P14410 | 2/20 | 0.58 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | STAT1 | P42224 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3191246 | 0.91 | NPC1 (1.00) | NPC1LMNAMAPTKDM4ERAB9A | |
| Nitrobenzene SCHEMBL27714762 | 0.91 | MAPT (0.68) | NPC1LMNAMAPTKDM4ERAB9A | |
| SCHEMBL22348661 | 0.88 | NPC1 (0.72) | NPC1LMNAMAPTKDM4ERAB9A | |
| SCHEMBL995829 | 0.87 | NPC1 (1.00) | NPC1LMNAMAPTKDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL27594584 | 0.86 | NPC1 (0.97) | NPC1LMNAMAPTKDM4ERAB9A | |
| Nitrobenzene SCHEMBL27656746 | 0.82 | LMNA (0.60) | NPC1LMNAMAPTKDM4ERAB9A | |
| SCHEMBL16562033 | 0.82 | SCD (1.00) | NPC1LMNAMAPTKDM4ERAB9A | |
| SCHEMBL4285954 | 0.81 | NPC1 (0.85) | NPC1LMNAMAPTRAB9ASCD | |
| Nitrobenzene SCHEMBL27591249 | 0.79 | NPC1 (0.55) | NPC1LMNAMAPTKDM4ERAB9A | |
| SCHEMBL2977438 | 0.79 | NPC1 (0.76) | NPC1LMNAMAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101090899-A | 2,5 and 2,6 disubstituted benzazole analogs useful as protein kinase inhibitors | 4SC AG (DE) | 2007-12-19 | — | — | CN | disclosed |